By David Nutt, Liam Nestor
A part of the Oxford Psychiatry Library sequence, this pocketbook is a transparent and accomplished assessment of the mind technology underpinning dependancy and the way this is helping clarify the present and destiny therapeutics for the variety of addictions, utilizing complete color pictures to reinforce knowing. Addiction specializes in the character of dependancy as a mind disease that features a diversity of other behavioural qualities akin to impulsivity and gift dependence, and discusses the severe position of kinetic and pharmacological elements. The textual content explains how the first pharmacological objectives of gear of abuse at the moment are understood, the relation to the variable nature of dependancy to assorted elements, and the way this can result in new techniques to therapy.
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Extra resources for Addiction (Oxford Psychiatry Library)
Koob GF and Volkow ND (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35, 217–38. Zorick T, Nestor L, Miotto K, et al. (2010). Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction, 105, 1809–18. 52 Chapter 4 Neurobiological processes in addiction Key points The brain controls necessary motivational and cognitive processes. These processes involve a network of independent and overlapping brain circuits. These processes involve reward, motivation, learning/ memory, and cognition.
E. holding multiple temporary pieces of information in the mind), attention, problem-solving, response inhibition, and 61 action monitoring. Evidence is continually emerging regarding the contributions of the PFC in the service of these cognitive control processes. The dorsolateral prefrontal cortex (DLPFC) is located in the lateral, upper, and anterior portions of the cerebrum. e. working memory). This area is also involved in response inhibition, verbal fluency, set shifting, planning, organizational skills, reasoning, and problem-solving.
The NAcc portion serves as a critical interface 57 between limbic and motor systems—linking motivation with action. The VTA-NAcc dopamine pathway is thought to be part of a gating mechanism. This mechanism directs the translation of motive states into motor responses. The OFC is also involved in the processes of motivation and drive for rewards. The OFC is located on the ventral surface of the PFC. It is connected with brain regions involved in dopamine-dependent reinforcement. The NAcc projects to the OFC, and the OFC also receives direct dopamine projections from the VTA.
Addiction (Oxford Psychiatry Library) by David Nutt, Liam Nestor