Download e-book for kindle: Advances in Lymphoma Research by Peter McLaughlin, Lester E. Robertson, Michael J. Keating

By Peter McLaughlin, Lester E. Robertson, Michael J. Keating (auth.), Fernando Cabanillas M.D., M. Alma Rodriguez M.D. (eds.)

ISBN-10: 1461368510

ISBN-13: 9781461368519

ISBN-10: 1461541298

ISBN-13: 9781461541295

Fernando Cabanillas In 1993, Fisher et al. released the result of a randomized trial evaluating 3 third-generation regimens opposed to the vintage CHOP mixture. For numerous years, the oncology neighborhood have been confident that the 3rd­ new release regimens have been sincerely more advantageous to cut. It got here as a surprise to many who there has been no distinction in consequence among the 4 fingers of this scientific trial. The logical end is that CHOP is nearly as good as any of the opposite regimens validated in that learn. regrettably, this wonderful learn has been misinterpreted through many as proving that there has now not been any growth within the box of lymphoma over the last two decades. additionally, it has resulted in a fatalistic perspective within the reasoning of many clinicians who suppose that 'nothing works greater than CHOP' and consequently that it isn't worthy trying out new medicinal drugs or constructing novel regimens. notwithstanding, the method during which we flow ahead within the oncology box is seldom by means of dramatic breakthroughs. usually, what seems initially look to be a leap forward seems later to be only a modest breakthrough. numerous steps ahead ultimately upload as much as a huge enhance, yet this improve is going left out as a result of sluggish nature of the method. during this quantity, we've got selected to debate numerous of those steps, which we suppose are basically creating a confident impression at the box of lymphomas and which quickly should still make an important distinction in healing results.

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Hickish T, Serafinowski P, Cunningham D, et al. (1993). 2-Chlorodeoxyadenosine: evaluation of a novel predominantly lymphocyte selective agent in lymphoid malignancies. Br J Cancer 67:139-143. 11. Saren A, Emanuele S, Kosty M, Koziol J, Ellison D, Piro L (1995). 2 chlorodeoxyadenosine activity in untreated, indolent non-Hodgkin's lymphoma. Blood 86:1710-1716. 11a. Piro LD, Petroni G, Barcos M, Johnson J, Saven A, Peterson B (1995). Bolus infusion of 2chlorodeoxyadenosine (2-CdA) as first-line therapy of low grade non-Hodgkin's lymphoma (NHL): CALGB 9153.

This entity was not recognized in the Working Formulation for Clinical Usage, and its description caused controversy among Fernando Cabanillas and M. Alma Rodriguez (eds), ADVANCES IN LYMPHOMA RESEARCH. Copyright © 1997. Kluwer Academic Publishers, Boston. All rights reserved. pathologists and confusion among clinicians [3]. Several years later, Weisenberger identified a distinctive type of follicular lymphoma that he called mantle zone lymphoma (MZL), due to the distinctive pattern exhibited by the malignant cells growing in wide mantles around benign germinal centers [4].

Carson DA, Kaye J, Seegmiller JE (1978). Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine. J ImmunoI121:1726-1731. 20. Carson DA, Wasson DB, Kaye J, et al. (1980). Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs towards malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc Nat! Acad Sci USA 77:6865-6869. 21. Avery T, Rehg J, Lumm W, Harwood FC, Santana VM, Blackley RL (1989). Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice.

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Advances in Lymphoma Research by Peter McLaughlin, Lester E. Robertson, Michael J. Keating (auth.), Fernando Cabanillas M.D., M. Alma Rodriguez M.D. (eds.)

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