By National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Nuclear and Radiation Studies Board, Committee on State of the Science of Nuclear Medicine
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Additional info for Advancing Nuclear Medicine Through Innovation
14 In its March 2004 Critical Path Report, the FDA stated that new tools were needed to distinguish earlier in the drug development process which candidates hold promise and which ones do not. Because only 8 percent of new medical compounds entering phase I testing reach the market, the FDA established eIND studies as a way of trying to reduce the time and cost of drug development. In an eIND study, the goal is to verify results observed in experimental models in humans and determine pharmacological properties rather than determine dose-limiting toxicities.
Based on data from CMS, the use of positron emission tomography (PET) is growing faster than the use of any other imaging modality. From 2000 to 2005, the average annual growth rate in the volume of PET and PET/CT procedures was 80 percent compared with 9 percent for non-PET nuclear medicine procedures, 11 percent for CT, and 13 percent for MRI (ACR 2007). 1). More importantly, the use of nuclear medicine procedures has improved patient care in many ways. Nuclear imaging allows physicians to cost-effectively obtain medical information that would otherwise be unavailable or would require more invasive procedures, such as surgery or biopsy.
Hot atom chemistrya work by Alfred Wolf, Michael Welch, and other scientists lays the groundwork for what will become radiopharmaceutical chemistry. William Eckelman and Powell Richards developed instant technetium kits. 1970s The efficient production of thallium-201 is developed by scientists at BNL. This procedure is still used today to assess reduced blood flow or tissue damage to the heart. NUCLEAR MEDICINE PET scanners that will later be successfully commercialized are developed by Michael Phelps, Edward Hoffman, and Michel Ter-Pogossian at Washington University based on earlier work by Gordon Brownell at the Massachusetts Institute of Technology (MIT) and James Robertson at BNL.
Advancing Nuclear Medicine Through Innovation by National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Nuclear and Radiation Studies Board, Committee on State of the Science of Nuclear Medicine